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 Should Men Get Tested? Half of all carriers of hereditary cancer mutations are male, yet most men have never heard of germline testing. New research, new genes, and new national guidelines are changing that calculus fast. For decades, the language of hereditary cancer genetics was implicitly female. "The breast cancer gene." Ovarian cancer syndromes. Women's health clinics. Men watched from the periphery, rarely asking whether they, too, might be carrying a ticking molecular clock. That oversight is now being corrected urgently by a convergence of genomic research, updated clinical guidelines, and a deeper understanding of how inherited mutations behave differently across sexes. The data are unambiguous: approximately 50% of all carriers of inherited, cancer-predisposing mutations in BRCA1 and BRCA2 are male, yet the implications for men's health have been systematically under-recognized compared to female carriers. A landmark January 2025 review published in JAMA On...